Introduction GERD unresponsive to medical therapies can be treated by laparoscopic Nissen fundoplication or endoluminal techniques. We describe our experience using the TIF procedure with the EsophyX device. The TIF procedure is not indicated in patients with a hiatal hernia larger than 2 cm. Performing a hiatal hernia repair (HHR) in those cases will make… Read more »
Endoscopic fundoplication: patient selection and technique
Gastroesophageal reflux disease (GERD) is a common condition that places a significant burden on the healthcare system. Additionally, there have been concerns raised about potential risks of long-term proton pump inhibitors. Laparoscopic anti-reflux surgery is currently the gold standard option for patients when surgery is planned. However, there continues to be interest in an endoscopic,… Read more »
Endoscopic Fundoplication: Effectiveness for Controlling Symptoms of Gastroesophageal Reflux Disease
OBJECTIVE: Transoral incisionless fundoplication (TIF) is a completely endoscopic approach to treat gastroesophageal reflux disease (GERD). We previously reported our initial results demonstrating safety and early effectiveness. We now present an updated experience describing outcomes with longer follow-up. METHODS: For a three-year period, TIF procedures were performed on 80 patients. Preoperative workup routinely consisted of… Read more »
Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption. However, few data exist regarding whether these medications increase the risk of clinical iron deficiency. METHODS: A community-based case-control study evaluated the association between acid-suppressing medication use and the subsequent risk of iron deficiency.… Read more »
An Overview of Transoral Incisionless Fundoplication and Magnetic Sphincter Augmentation for GERD
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Long-term benefit of transoral incisionless fundoplication using the EsophyX device for the management of gastroesophageal reflux disease responsive to medical therapy
Transoral incisionless fundoplication (TIF) using the EsophyX device has been shown to be effective and safe in patients with Gastroesophageal reflux disease (GERD); however, the subset of patients that would mostly benefit from this technique remains unknown. The aim of this study was to evaluate the long-term efficacy and safety of the TIF procedure in… Read more »
Proton Pump Inhibitor Use Increases the Associated Risk of First-Time Ischemic Stroke. A Nationwide Cohort Study
Introduction: Use of proton pump inhibitors has been linked with endothelial dysfunction and increased risk of myocardial infarction. Hypothesis: We hypothesize that use of proton pump inhibitors (PPIs) increases the risk of ischemic stroke. Methods: Using nationwide Danish registries, we performed a retrospective cohort study. We identified all individuals above 30 years, who had an… Read more »
Endoluminal Therapy for Gastroesophageal Reflux Disease: In Between the Pill and the Knife?
Gastroesophageal reflux disease (GERD) is a chronic disease characterized by symptoms of heartburn and acid regurgitation. Uncontrolled GERD can significantly impact quality of life, can lead to complications, and increases the risk of esophageal cancer. Over the past few decades, there has been an increasing prevalence of GERD among adults in Western populations. The use… Read more »
Transoral fundoplication offers durable symptom control for chronic GERD: 3-year report from the TEMPO randomized trial with a crossover arm
BACKGROUND: Four randomized controlled trials have demonstrated the short-term efficacy and safety of transoral esophagogastric fundoplication (TF) performed with the EsophyX®device in eliminating troublesome gastroesophageal reflux disease (GERD) symptoms in well-selected patient populations. The aim of this study was to assess the durability of these outcomes at 3 years post-procedure. METHODS: The TF EsophyX versus Medical… Read more »
Proton pump inhibitors use and change in bone mineral density
OBJECTIVE: Limited data are available reporting the effect of proton pump inhibitor (PPI) use on changes in bone mineral density (BMD). The aim of this study was to investigate the relationship between PPI use and BMD. METHODS: The current cross-sectional study included 80 patients (31 male and 49 female) aged 20-45 years old without history… Read more »